The threat from Isshiki Otsutsuki was felt strongly during the latest Boruto storyline: Naruto the Next Generations. The member of the alien clan who wants to penetrate the earth to get the life energy, and for this he needs Kawaki, but also the protagonist Boruto will be useful for his purpose.
However, the twists and turns in Boruto: Naruto, The Next Generations, Chapter 53 completely messed up the cards on the table. While Boruto was knocked out, Naruto, Sasuke, and Kawaki managed to stop Isshiki's attempts to replant the boy's karma. Their strategy worked and Isshiki eventually crumbled into a pile of dust. While the trio was partying However, Momoshiki takes possession of the unconscious protagonist's body and catches Sasuke in the eye and robs him of his most powerful weapon.
Now that Momoshiki has awakened, he can become that true antagonist of Boruto: Naruto the next generations. In fact, the process Isshiki had to deal with can also be done by Momoshiki, who in a few years can take possession of Boruto's body and then sacrifice his new body and replant the karma in Kawaki, following the same plan as Isshiki in executes in reverse order.
In short, the The Otsutsuki threat is not over and under the conditions in which the protagonists are Boruto's most difficult game: Naruto, the next generations, has not yet started.